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지적재산권

R&D

지적재산권

Home R&D 지적재산권

독성과 부작용이 없는 신 의약품 원료의 개발
신물질,신약 및 신기능성 건강식품소재 개발

NO. Publication
1

MOO RIM KANG, CHANG WOO LEE1, IG JUN CHO, MYEONG YOUL LEE, JUNG HYU SHIN1, SOO JIN OH, JIEUN YUN, WON KEE YOON, SANG-BAE HAN, EUN EAI KIM, SONG-HAE BOK and JONG SOON KANG, ‘BETAINE SUPPLEMENTATION IMPROVES BENEFICIAL EFFECTS OF BOXTHORN (LYCIUM CHINENSE MILL.) LEAF ON BODY WEIGHT/BODY FAT INCREASE AND PLASMA/LIVER TRIGLYCERIDES ACCUMULATION IN HIGH-FAT DIET-FED C57BL/6 MICE‘ Journal of Food Biochemistry 38, 620-626, 2014
2 Un Ju Jung, Jeong-Sun Lee, Song-Hae Bok, Myung-Sook Choi. 2011. Effects of Extracts of Persimmon Leaf, Buckwheat Leaf, and Chinese Matrimony Vine Leaf on Body Fat and Lipid Metabolism in Rats. J Korean Soc Food Sci Nutr 40:1215-1226
3 Jeong-sun Lee, Song-Hae Bok, Seon-Min Jeon, Hye-jin Kim, Kyung-Min Do, Yong-Bok Park, Myung-sook Choi. 2010. Antihyperlipidemic effects of buckwheat leaf and flower in rats fed a high-fat diet. Food Chemistry 119:235-240.
4 Myoung-Nam Woo, Song-Hae Bok, Myung-Sook, Choi. 2009. Hypolipidemic and body fat-lowering effects of Fatclean in rats fed a high-fat diet. Food and Chemical Toxicology 47:2076-2082.
5 Myoung-Nam Woo. Song-Hae Bok, Mi-Kyung Lee, Hye-Jin Kim, Seon-Min Jeon, Gieong-Min Do, Su Kyung Shin, Tae Yeul Ha, Myung-Sook Choi. 2008. Anti-Obesity and Hypolipidemic Effects of a Proprietary Herb and Fiber Combination (S&S PWH) in Rats Fed High-Fat Diets. J Med Food 11:169-178.
6 Mi-Kyung Lee, Young Bok Park, Surk-Sik Moon, Song Hae Bok, Dong-Ju Kim, Tae-Youl Ha, Tae-Sook Keong, Kyu-Shik Keong, Myung-Sook Choi. 2007. Hypocholesterolemic and antioxidant properties of 3-(4-hydroxyl)propanoic acid derivatives in high-cholesterol fed rats. Chemico-Biological Interactions 170:9-19.
7 J.S. Lee, M.K. Lee, T.Y. Ha, S.H. Bok, H.M. Park, K.S. Jeong, M.N. Woo, G.-M. Do, J.-Y.Yeo, M.-S. Choi. 2006. Supplementation of Whole persimmon leaf improves lipid profiles and suppresses body weight gain in rats fed high-fat diet. Food and Chemical Toxicology 44:1875-1883.
8 Soon-Ja Kim, Song-Hae Bok, Sangku-Lee, Mi-Kyung Lee, Yong Bok Park, Hye-Jin Kim, Myung-Sook Choi. 2005. Lipid-Lowering Efficacy of 3,4-Di(OH)-Phenylpropionic L-Leucine in high-cholestero fed rats. J BIOCHEM MOLECULAR TOXICOLOGY 19:25-31.
9 Soon-Ja Kim, Song-Hae Bok, Sangku-Lee, Hye-Jin Kim, Mi-Kyung Lee, Yong Bok Park, Myung-Sook Choi. 2005. Anticholesterolemic effect of 3,4-di(OH)-phenylpropionic amides in high-cholesterol fed rats. Toxicology and Applied Pharmacology 208:29-36.
10 Park, E.-J., Lee, S., Jeong, T.-S., Bok, S.-H., Lee, M.-K., Park, Y. B., Choi, M.-S. 2004. Effect of 3,4-di(OH)-Cinnamate Synthetic Derivative on Plasma and Hepatic cholesterol level and Antioxidant enzyme activities in high cholesterol-fed rats. J. Biochem. Mol. Tox. 18:279-287.
11 Gab-Sun Choi, Sangku Lee, Tae-Sook Jeong, Mi-Kyung Lee, Jeong-Sun Lee, Un Ju Jung, Hye-Jin Kim, Yong Bok Park, Song-Hae Bok, Myung-Sook Choi. 2004. Evaluation of hesperetin 7-O-lauryl ether as lipid-lowering agent in high-cholesterol-fed rats. Bioorganic & Medicinal Chemistry 12 :3599-3605.
12 Sangku Lee, Chul-Ho Lee, Surk-Sik Moon, Eungsoo Kim, Chul-Tae Kim, Bang-Hyun Kim, Song-Hae Bok,Tae-Sook Jeong. 2003. Naringenin Derivatives as Anti-atherogenic Agents. Bioorg. Med. Chem. Lett 13:3901-3903.
13 Tae-Sook Jeong, Eun Eai Kim, Chul-Ho Lee, Jung-Hoon Oh,Surk-Sik Moon, Woo Song Lee, Goo-Taeg Oh, Sangku Lee, Song-Hae Bok. 2003. Hypocholesterolemic Activity of Hesperetin Derivatives. Bioorg. Med. Chem. Lett 13:2663-2665.
14 Mi-Kyung Lee, Eun-Mi Park, Song-Hae Bok, Un Ju Jung, Ji-Young Kim, Yong Bok Park, Tae-Lin Huh, Oh-Shin Kwon, and Myung-Sook Choi. 2003. Two Cinnamate Derivatives Produce Similar Alteration in mRNA Expression and Activity of Antioxidant Enzymes in Rats. J BIOCHEM MOLECULAR TOXICOLOGY 17:255-262
15 Mi-Kyung Lee, Surk-Sik Moon, Seung-Eun Lee, Song-Hae Bok, Tae-Sook Jeong, Yong Bok Park and Myung-Sook Choi. 2003. Naringenin 7-0-cetyl Ether as Ingibitor of HMG-CoA Reductase and Modulator of Plasma and Hepatic Lipids in High Cholesterol-Fed Rats. Bioorganic & Medicinal Chemitry 11:393-398 .
16 Sangku Lee, Chul-Ho Lee, Jung-Hoon Oh, Eun Eai Kim, Yang-Kyu Choi, Eun-Hee Kim, Woo Song Lee, Song-Hae Bok and Tae-Sook Jeong. 2003. Anti-Atherogenic Effects of 3,4-Dihydroxy Hydrocinnamides. Bioorganic & Medicinal Chemistry Letters 13:2681-2682.
17 Jeong-Sun Lee, Song-Hae Bok, Tae-Sook Jeong, Surk-Sik Moon, Yong Bok Park, Myung-Sook Choi. 2003. 4-Hydroxycinnamate lowers plasma and hepatic lipids without changing antioxidant enzyme activities. Annals of Nutrition Metabolism 47:144-151.
18 Sung-Yeon Cho, Sang-Joon Park, Myung-Ja Kwon, Tae-Sook Jeong, Song-Hae Bok, Woo-Young Choi, Won-Il Jeong, Si-Yun Ryu, Sun-Hee Do, Cha-Soo Lee, Jae-Chan Song and Kyu-Shik Jeong. 2003. Quercetin suppresses proinflammatory cytokines production through MAP kinases and NF-κB pathway in lipopolysaccharide-stimulated macrophage. Molecular and Cellular Biochemistry 243:153-160.
19 Cho KH, Lee JY, Choi MS, S. H. Bok, Park YB. 2002. Interaction of CETP Inhibitory Peptide and Lipoprotein Substrates in Cholesteryl Ester Transfer Assay: Relationship Between Association Properties and Inhibitory Activities. Lipids 37:641-646.
20 Myung-Sook Choi, Sun-Young Park, Seon-Min Jeon, Yong Bok Park, Soon-Jae Lee, Tae-Sook Jeong, Song-Hae Bok. 2002. Effect of Rutin and Tannic Acid Supplements on Cholesterol Metabolism in Rats. J. Nutrition Research (SCI) 22:283-295.
21 Bok, S. H., S. Y. Park, Y. B. Park, M. K. Lee, S. M. Jeon, T. S. Jeong, and M. S. Choi. 2002. Quercetin dihydrate and gallate supplements lower plasma and hepatic lipids and change activities of hepatic antioxidant enzymes in high cholesterol-fed rats. Submitted. Int. J. Vitam. Nur. Res(SCI) 72:161-169.
22 Mi-Kyung Lee, Song-Hae Bok, Tae-Sook Jeong, Surk-Sik Moon, Soon-Chang Cho, Yong Bok Park and Myung-Sook Choi. 2002. Supplementation of Naringenin and Its Synthetic Derivative Alters Antioxidant Enzyme Activities of Erythrocyte and Liver in High Cholesterol-Fed Rats. Bioorganic and Medicinal Chemistry (SCI) 10:2239-2244.
23 Ji Young Kim, Moon Kyoo Jang, Sang-Sook Lee, Myung-Sook Choi, Song-Hae Bok, Goo Taeg Oh, and Yong Bok Park. 2002. Rab7 gene is up-regulated by cholesterol-rich diet in the liver and artery. Biochem. and Biophysical Research Communications. 293:375-382.
24 Kyung-Hyun Cho, Yong Won Shin, Myung-Sook Choi, Song-Hae Bok, Sang-Hee Jang and Yong Bok Park. 2002. In Vivo Effects of CETP Inhibitory Peptides in Hypercholesterolemic Rabbit and Cholesteryl Ester Transfer Protein-Transgenic Mice. J. of Biochem. and Mol. Biology 35:172-177.
25 Seon-Min Jeon, Song-Hae Bok, Moon-Kyoo Jang, Yeon-Hee Kim, Kyung-Tak Nam, Tae-Sook Jeong, Yong Bok Park, Myung-Sook Choi. 2002. Comparison of Antioxidant Effects of Naringin with Probucol in Cholesterol-Fed Rabbits. Clinica Chimica Acta (SCI) 317:181-190.
26 Hyo Soo Kim, Tae Sook Jeong, Song Hae Bok, Song Jun Choi. 2001. Naringin has an Anti atherogenic Effect with the inhibition of Intercellular Adhesion Molecule-1 in hypercholesterolemic rabbits. J. of Cardiovascular Pharmacology 38:947-955.
27 Jeong-Sun Lee, Myung-Sook Choi, Seon-Min Jeon, Tae-Sook Jeong, Yong Bok Park, Mi Kyung Lee, Song-Hae Bok. 2001. Lipid-lowering and antioxidative activities of 3,4-di(OH)-cinnamate and 3,4-di(OH)-hydrocinnamate in cholesterol-fed rats. Clinica Chimica Acta (SCI) 314:221-229.
28 Myung-Sook Choi, Kyung-Min Do, Yong-Bok Park, Seon-Min Jeon, Tae-Sook Jeong Yeoun-Kyung Lee, Mi-Kyung Lee, Song-Hae Bok. 2001. Effect of Naringin Supplementation on Cholesterol Metabolism and Antioxidant Status in Rats Fed High Cholesterol with Different Levels of Vitamin E, Annals of Nutrition & Metabolism 45:193-201.
29 Chul-Ho Lee, Tae-Sook Jeong, Yang-Kyu Choi, Byung-Hwa Hyun, Goo-Taeg Oh, Eun-Hee Kim, Ju-Ryoung Kim, Jang-Il Han, and Song-Hae Bok. 2001. Anti-Atherogenic Effect of Citrus Flavonoids, Naringin and Naringenin, Associated with Hepatic ACAT and Aortic VCAM-1 and MCP-1 in High Cholesterol-Fed Rabbits. BBRC284:681-688.
30 Yong Bok Park, Kyung-Min Do, Song-Hae Bok, Mi-Kyung Lee, Tae-Sook Jeong and Myung-Sook Choi. 2001. Interactive Effect of Hesperidin and Vitamin E Supplements on Cholesterol Metabolism in High Cholesterol-Fed Rats. Int. J. Vitam. Nutr. Res(SCI) 71:36-44.
31 Bok, S. H., Shin, Y. W., Bae, K. H., Jeoug, T. S., Kwon, Y. K., Park, Y. B. and Choi, M. S. 2000. Effects of naringin and lovastatin on plasma and hepatic lipids in high-fat and high-cholesterol fed rats. Nutrition Research. 20:1007-1015.
32 Lee, S. H., Jeong, T. S., Park, Y. B., Kwon, Y. K., Choi, M. S. and Bok, S. H. 1999. Hypocholesterolemic Effect of hesperetin mediated by inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase and acyl coenzyme A: cholesterol acyltransferase in rats fed high-cholesterol diet high-cholesterol diet. Nutrition Research 19:1245-1258.
33 Shin, Y. W., Bok, S. H., Jeong, T. S., Bae, K. H., Jeoung, N. H., Choi, M. S., and Park, Y. B. 1999. Hypocholesterolemic Effect of Naringin Associated with Hepatic Cholesterol Regulating Enzyme Changes in Rats. International Journal of Vitamin and Nutrition 69:341-347.
34 Bok, S. H., Lee, S. H., Park, Y. B., K. H., Son, K. H., Jeong, T. S. and Choi, M. S. 1999. Plasma and Hepatic Cholesterol and Hepatic Activities of 3-hydroxy-3-methyl-glutaryl-CoA Reductase and Acyl CoA: Cholesterol Transferase are Lower in Rats fed Citrus Peel Extract or a Mixture of Citrus Bioflavonoids, J. of Nutrition 129: 1182-1185.
35 Kwon B. M., J. Y. Nam, S. H. Lee, T. S. Jeong, Y. K. Kim, S. H. Bok. 1996. Isolation of cholesteryl ester transfer protein
inhibitors from Panax ginseng Roots. Chem. Pharm. Bull 44:444-445.